Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study.

ABSTRACT:

Background

Obesity has been shown to be associated with depression and it has been suggested that higher body mass index (BMI) increases the risk of depression and other common mental disorders. However, the causal relationship remains unclear and Mendelian randomisation, a form of instrumental variable analysis, has recently been employed to attempt to resolve this issue.

Aims

To investigate whether higher BMI increases the risk of major depression.

Method

Two instrumental variable analyses were conducted to test the causal relationship between obesity and major depression in RADIANT, a large case-control study of major depression. We used a single nucleotide polymorphism (SNP) in FTO and a genetic risk score (GRS) based on 32 SNPs with well-established associations

SUBMITTER: Hung CF 

PROVIDER: S-EPMC4076654 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature