A systemic review of glutathione S-transferase P1 Ile105Val polymorphism and colorectal cancer risk.

ABSTRACT:

Objectives

To investigate the correlation between glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism and colorectal cancer (CRC) risk.

Methods

Studies were identified to investigate the association between GSTP1 Ile105Val polymorphism and CRC risk. Systematic computerized searches of the PubMed, Chinese National Knowledge Infrastructure, WANFANG and SinoMed were performed. Summary odds ratios (OR) and 95% confidence intervals (95% CI) were used to measure GSTP1 Ile105Val polymorphisms and CRC risk.

Results

A total of 23 retrospective studies were included in the meta-analysis. During all studies including 6,981 cases and 8,977 controls, sample sizes ranged from 146 to 2,144. Overall, the pooled results revealed that Ile105Val polymorphism was not associated w

SUBMITTER: Song QB 

PROVIDER: S-EPMC4076718 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature