A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility.

ABSTRACT: Tobacco smoke is the major environmental risk factor underlying lung carcinogenesis. However, approximately one-tenth smokers develop lung cancer in their lifetime indicating there is significant individual variation in susceptibility to lung cancer. And, the reasons for this are largely unknown. In particular, the genetic variants discovered in genome-wide association studies (GWAS) account for only a small fraction of the phenotypic variations for lung cancer, and gene-environment interactions are thought to explain the missing fraction of disease heritability. The ability to identify smokers at high risk of developing cancer has substantial preventive implications. Thus, we undertook a gene-smoking interaction analysis in a GWAS of lung cancer in Han Chinese population using a two-phase

SUBMITTER: Zhang R 

PROVIDER: S-EPMC4076813 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature