Noncontaminated dietary oats may hamper normalization of the intestinal immune status in childhood celiac disease.

ABSTRACT:

Objectives

Life-long, strict gluten-free diet (GFD) is the only treatment for celiac disease (CD). Because there is still uncertainty regarding the safety of oats for CD patients, the aim was to investigate whether dietary oats influence the immune status of their intestinal mucosa.

Methods

Paired small intestinal biopsies, before and after >11 months on a GFD, were collected from children with CD who were enrolled in a randomized, double-blind intervention trial to either of two diets: standard GFD (GFD-std; n=13) and noncontaminated oat-containing GFD (GFD-oats; n=15). Expression levels of mRNAs for 22 different immune effector molecules and tight junction proteins were determined by quantitative reverse transcriptase (RT)-PCR.

Results

The number of mRNAs that remai

SUBMITTER: Sjoberg V 

PROVIDER: S-EPMC4077043 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature