Linking intestinal homeostasis and liver disease.

ABSTRACT:

Purpose of review

Interactions of the gut microbiome with the host are important in health and disease. Microbial translocation releases bacterial products that play a key role in progression of chronic liver disease by promoting hepatic injury and inflammation. Although this has long been recognized, we are just beginning to understand the circumstances under which the gut becomes leaky and to discover bacterial metabolites that promote liver disease. In this review, we will summarize recent findings from the last 2 years.

Recent findings

Chronic liver disease is associated with an altered microbiome with both qualitative (dysbiosis) and quantitative (overgrowth) differences. This can be viewed as a loss of the symbiotic relationship between the microflora and the host. An

SUBMITTER: Schnabl B 

PROVIDER: S-EPMC4077188 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature