A systems biology investigation of neurodegenerative dementia reveals a pivotal role of autophagy.

ABSTRACT:

Background

Neurodegenerative dementia comprises chronic and progressive illnesses with major clinical features represented by progressive and permanent loss of cognitive and mental performance, including impairment of memory and brain functions. Many different forms of neurodegenerative dementia exist, but they are all characterized by death of specific subpopulation of neurons and accumulation of proteins in the brain. We incorporated data from OMIM and primary molecular targets of drugs in the different phases of the drug discovery process to try to reveal possible hidden mechanism in neurodegenerative dementia. In the present study, a systems biology approach was used to investigate the molecular connections among seemingly distinct complex diseases with the shared clinical symp

SUBMITTER: Caberlotto L 

PROVIDER: S-EPMC4077228 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature