Direct C-H trifluoromethylation of di- and trisubstituted alkenes by photoredox catalysis.

ABSTRACT:

Background

Trifluoromethylated alkene scaffolds are known as useful structural motifs in pharmaceuticals and agrochemicals as well as functional organic materials. But reported synthetic methods usually require multiple synthetic steps and/or exhibit limitation with respect to access to tri- and tetrasubstituted CF3-alkenes. Thus development of new methodologies for facile construction of Calkenyl-CF3 bonds is highly demanded.

Results

The photoredox reaction of alkenes with 5-(trifluoromethyl)dibenzo[b,d]thiophenium tetrafluoroborate, Umemoto's reagent, as a CF3 source in the presence of [Ru(bpy)3](2+) catalyst (bpy = 2,2'-bipyridine) under visible light irradiation without any additive afforded CF3-substituted alkenes via direct Calkenyl-H trifluoromethylation. 1,1-Di- and

SUBMITTER: Tomita R 

PROVIDER: S-EPMC4077392 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature