Consecutive isocyanide-based multicomponent reactions: synthesis of cyclic pentadepsipeptoids.

ABSTRACT: The synthesis of six cyclic depsipeptoids inspired by the natural depsipeptide sansalvamide A is described. An efficient and fast synthetic strategy was developed using a combination of consecutive isocyanide-based multicomponent reactions (Ugi and Passerini reactions). This methodology can be used to access a variety of cyclic oligodepsipeptoids.

SUBMITTER: Barreto Ade F 

PROVIDER: S-EPMC4077530 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature