Cystatin C, a novel indicator of renal function, reflects severity of cerebral microbleeds.

ABSTRACT:

Background

Chronic renal insufficiency, diagnosed using creatinine based estimated glomerular filtration rate (GFR) or microalbumiuria, has been associated with the presence of cerebral microbleeds (CMBs). Cystatin C has been shown to be a more sensitive renal indicator than conventional renal markers. Under the assumption that similar pathologic mechanisms of the small vessel exist in the brain and kidney, we hypothesized that the levels of cystatin C may delineate the relationship between CMBs and renal insufficiency by detecting subclinical kidney dysfunction, which may be underestimated by other indicators, and thus reflect the severity of CMBs more accurately.

Methods

Data was prospectively collected for 683 patients with ischemic stroke. The severity of CMBs was catego

SUBMITTER: Oh MY 

PROVIDER: S-EPMC4077563 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature