Could (18) F-DPA-714 PET imaging be interesting to use in the early post-stroke period?

ABSTRACT:

Background

Cerebral stroke is a severe and frequent condition that requires rapid and reliable diagnosis. If administered shortly after the first symptoms manifest themselves, IV thrombolysis has been shown to increase the functional prognosis by restoring brain reperfusion. However, a better understanding of the pathophysiology of stroke should help to identify potential new therapeutic targets. Stroke is known to induce an inflammatory brain reaction that involves overexpression of the 18-kDa translocator protein (TSPO) in glial cells and infiltrated leukocytes, which can be visualised by positron emission tomography (PET). We aimed to evaluate post-stroke neuroinflammation using the PET TSPO radioligand (18) F-DPA-714.

Methods

Nine patients underwent (18) F-DPA-714 PET an

SUBMITTER: Ribeiro MJ 

PROVIDER: S-EPMC4077629 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature