JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI.

ABSTRACT:

Introduction

Breast cancer is a worldwide health problem and the leading cause of cancer death among females. We previously identified Jumonji domain containing 2A (JMJD2A) as a critical mediator of breast cancer proliferation, migration and invasion. We now report that JMJD2A could promote breast cancer progression through transcriptional repression of the tumor suppressor aplasia Ras homolog member I (ARHI).

Methods

Immunohistochemistry was performed to examine protein expressions in 155 cases of breast cancer and 30 non-neoplastic tissues. Spearman correlation analysis was used to analyze the correlation between JMJD2A expression and clinical parameters as well as several tumor regulators in 155 cases of breast cancer. Gene and protein expressions were monitored by quanti

SUBMITTER: Li LL 

PROVIDER: S-EPMC4077733 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature