Genetic polymorphisms in ZFHX3 are associated with atrial fibrillation in a Chinese Han population.

ABSTRACT:

Background

The gene zinc finger homeobox 3 (ZFHX3) encodes a transcription factor with cardiac expression and its genetic variants are associated with atrial fibrillation (AF). We aimed to explore the associations between single nucleotide polymorphisms (SNPs) of ZFHX3 and the risk of AF in a Chinese Han population.

Methods

We genotyped eight SNPs, including seven potentially functional SNPs and one previously reported SNP by using the middle-throughput iPLEX Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression models.

Results

We enrolled a total of 1,593 Chinese Han origin individuals in the study, including 597 AF patients and 996 non-AF controls. Logistic regression analyses revealed that potential

SUBMITTER: Liu Y 

PROVIDER: S-EPMC4077770 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature