RPM-1 is localized to distinct subcellular compartments and regulates axon length in GABAergic motor neurons.

ABSTRACT:

Background

The PAM/Highwire/RPM-1 (PHR) proteins are conserved signaling proteins that regulate axon length and synapse formation during development. Loss of function in Caenorhabditis elegans rpm-1 results in axon termination and synapse formation defects in the mechanosensory neurons. An explanation for why these two phenotypes are observed in a single neuronal cell has remained absent. Further, it is uncertain whether the axon termination phenotypes observed in the mechanosensory neurons of rpm-1 mutants are unique to this specific type of neuron, or more widespread defects that occur with loss of function in rpm-1.

Results

Here, we show that RPM-1 is localized to both the mature axon tip and the presynaptic terminals of individual motor neurons and individual mechanosens

SUBMITTER: Opperman KJ 

PROVIDER: S-EPMC4077836 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature