Gene expression signature for biliary atresia and a role for interleukin-8 in pathogenesis of experimental disease.

ABSTRACT:

Unlabelled

Biliary atresia (BA) is a progressive fibroinflammatory obstruction of extrahepatic bile ducts that presents as neonatal cholestasis. Due to the overlap in clinical, biochemical, and histological features with other causes of cholestasis, the diagnosis requires an intraoperative cholangiogram. Thus, we determined whether diseased livers express a gene expression signature unique to BA. Applying stringent statistical analysis to a genome-wide liver expression platform of 64 infants with BA at the time of diagnosis, 14 age-appropriate subjects with intrahepatic cholestasis as diseased controls and seven normal controls, we identified 15 genes uniquely expressed in BA with an accuracy of 92.3%. Among these genes, IL8 and LAMC2 were sufficient to classify subjects with BA di

SUBMITTER: Bessho K 

PROVIDER: S-EPMC4077977 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature