A comprehensive look at transcription factor gene expression changes in colorectal adenomas.

ABSTRACT:

Background

Biological processes are controlled by transcription networks. Expression changes of transcription factor (TF) genes in precancerous lesions are therefore crucial events in tumorigenesis. Our aim was to obtain a comprehensive picture of these changes in colorectal adenomas.

Methods

Using a 3-pronged selection procedure, we analyzed transcriptomic data on 34 human tissue samples (17 adenomas and paired samples of normal mucosa, all collected with ethics committee approval and written, informed patient consent) to identify TFs with highly significant tumor-associated gene expression changes whose potential roles in colorectal tumorigenesis have been under-researched. Microarray data were subjected to stringent statistical analysis of TF expression in tumor vs. norma

SUBMITTER: Vonlanthen J 

PROVIDER: S-EPMC4078005 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature