Expression and function of the progesterone receptor in human prostate stroma provide novel insights to cell proliferation control.

ABSTRACT:

Context

Like other tissues, the prostate is an admixture of many different cell types that can be segregated into components of the epithelium or stroma. Reciprocal interactions between these 2 types of cells are critical for maintaining prostate homeostasis, whereas aberrant stromal cell proliferation can disrupt this balance and result in diseases such as benign prostatic hyperplasia. Although the androgen and estrogen receptors are relatively well studied for their functions in controlling stromal cell proliferation and differentiation, the role of the progesterone receptor (PR) remains unclear.

Objective

The aim of the study was to investigate the expression and function of the PR in the prostate.

Design and setting

Human prostate biopsies, renal capsule xenograft

SUBMITTER: Yu Y 

PROVIDER: S-EPMC4078099 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature