Supplemental carnitine affects the microRNA expression profile in skeletal muscle of obese Zucker rats.

ABSTRACT:

Background

In the past, numerous studies revealed that supplementation with carnitine has multiple effects on performance characteristics and gene expression in livestock and model animals. The molecular mechanisms underlying these observations are still largely unknown. Increasing evidence suggests that microRNAs (miRNAs), a class of small non-coding RNA molecules, play an important role in post-transcriptional regulation of gene expression and thereby influencing several physiological and pathological processes. Based on these findings, the aim of the present study was to investigate the influence of carnitine supplementation on the miRNA expression profile in skeletal muscle of obese Zucker rats using miRNA microarray analysis.

Results

Obese Zucker rats supplemented with

SUBMITTER: Keller J 

PROVIDER: S-EPMC4078242 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature