Ontology highlight
ABSTRACT:
SUBMITTER: Bardelli A
PROVIDER: S-EPMC4078408 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Cancer discovery 20130602 6
EGF receptor (EGFR)-targeted monoclonal antibodies are effective in a subset of metastatic colorectal cancers. Inevitably, all patients develop resistance, which occurs through emergence of KRAS mutations in approximately 50% of the cases. We show that amplification of the MET proto-oncogene is associated with acquired resistance in tumors that do not develop KRAS mutations during anti-EGFR therapy. Amplification of the MET locus was present in circulating tumor DNA before relapse was clinically ...[more]