Impairment in extinction of contextual and cued fear following post-training whole-body irradiation.

ABSTRACT: Because of the use of radiation in cancer therapy, the risk of nuclear contamination from power plants, military conflicts, and terrorism, there is a compelling scientific and public health interest in the effects of environmental radiation exposure on brain function, in particular hippocampal function and learning and memory. Previous studies have emphasized changes in learning and memory following radiation exposure. These approaches have ignored the question of how radiation exposure might impact recently acquired memories, which might be acquired under traumatic circumstances (cancer treatment, nuclear disaster, etc.). To address the question of how radiation exposure might affect the processing and recall of recently acquired memories, we employed a fear conditioning paradigm wherein

SUBMITTER: Olsen RH 

PROVIDER: S-EPMC4078460 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature