A bombesin-shepherdin radioconjugate designed for combined extra- and intracellular targeting.

ABSTRACT: Radiolabeled peptides which target tumor-specific membrane structures of cancer cells represent a promising class of targeted radiopharmaceuticals for the diagnosis and therapy of cancer. A potential drawback of a number of reported radiopeptides is the rapid washout of a substantial fraction of the initially delivered radioactivity from cancer cells and tumors. This renders the initial targeting effort in part futile and results in a lower imaging quality and efficacy of the radiotracer than achievable. We are investigating the combination of internalizing radiopeptides with molecular entities specific for an intracellular target. By enabling intracellular interactions of the radioconjugate, we aim at reducing/decelerating the externalization of radioactivity from cancer cells. Using the

SUBMITTER: Fischer CA 

PROVIDER: S-EPMC4078514 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature