Plasticity of hydrogen bond networks regulates mechanochemistry of cell adhesion complexes.

ABSTRACT: Mechanical forces acting on cell adhesion receptor proteins regulate a range of cellular functions by formation and rupture of noncovalent interactions with ligands. Typically, force decreases the lifetimes of intact complexes ("slip bonds"), making the discovery that these lifetimes can also be prolonged ("catch bonds") a surprise. We created a microscopic analytic theory by incorporating the structures of selectin and integrin receptors into a conceptual framework based on the theory of stochastic equations, which quantitatively explains a wide range of experimental data (including catch bonds at low forces and slip bonds at high forces). Catch bonds arise due to force-induced remodeling of hydrogen bond networks, a finding that also accounts for unbinding in structurally unrelated integ

SUBMITTER: Chakrabarti S 

PROVIDER: S-EPMC4078813 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature