Cis-regulatory mechanisms of gene expression in an olfactory neuron type in Caenorhabditis elegans.

ABSTRACT: The generation of cellular diversity is dependent on the precise spatiotemporal regulation of gene expression by both cis- and trans-acting mechanisms. The developmental principles regulating expression of specific gene subsets in individual cell types are not fully understood. Here we define the cis-regulatory mechanisms driving expression of cell-selective and broadly expressed genes in vivo in the AWB olfactory neuron subtype in C. elegans. We identify an element that is necessary to drive expression of neuron-selective chemoreceptor genes in the AWB neurons, and show that this element functions in a context-dependent manner. We find that the expression of broadly expressed sensory neuronal genes in the AWB neurons is regulated by diverse cis- and trans-regulatory mechanisms that act pa

SUBMITTER: Nokes EB 

PROVIDER: S-EPMC4078920 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature