Universal pacemaker of genome evolution in animals and fungi and variation of evolutionary rates in diverse organisms.

ABSTRACT: Gene evolution is traditionally considered within the framework of the molecular clock (MC) model whereby each gene is characterized by an approximately constant rate of evolution. Recent comparative analysis of numerous phylogenies of prokaryotic genes has shown that a different model of evolution, denoted the Universal PaceMaker (UPM), which postulates conservation of relative, rather than absolute evolutionary rates, yields a better fit to the phylogenetic data. Here, we show that the UPM model is a better fit than the MC for genome wide sets of phylogenetic trees from six species of Drosophila and nine species of yeast, with extremely high statistical significance. Unlike the prokaryotic phylogenies that include distant organisms and multiple horizontal gene transfers, these are simple

SUBMITTER: Snir S 

PROVIDER: S-EPMC4079209 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature