From pharmacogenetics to pharmacogenomics: the way toward the personalization of antidepressant treatment.

ABSTRACT:

Objective

Major depressive disorder is the most common psychiatric disorder, worldwide, yet response and remission rates are still unsatisfactory. The identification of genetic predictors of antidepressant (AD) response could provide a promising opportunity to improve current AD efficacy through the personalization of treatment. The major steps and findings along this path are reviewed together with their clinical implications and limitations.

Method

We systematically reviewed the literature through MEDLINE and Embase database searches, using any word combination of "antidepressant," "gene," "polymorphism," "pharmacogenetics," "genome-wide association study," "GWAS," "response," and "adverse drug reactions." Experimental works and reviews published until March 2012 were coll

SUBMITTER: Fabbri C 

PROVIDER: S-EPMC4079233 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature