Systemic delivery of estradiol, but not testosterone or progesterone, alters very low density lipoprotein-triglyceride kinetics in postmenopausal women.

ABSTRACT:

Context

Sexual dimorphism in plasma triglyceride (TG) metabolism is well established but it is unclear to what extent it is driven by differences in the sex hormone milieu. RESULTS from previous studies evaluating the effects of sex steroids on plasma TG homeostasis are inconclusive because they relied on orally administered synthetic hormone preparations or evaluated only plasma lipid concentrations but not kinetics.

Objective

The purpose of this study was to evaluate the effects of systemically delivered 17β-estradiol, progesterone, and T on very low density lipoprotein-triglyceride (VLDL-TG) concentration and kinetics in postmenopausal women.

Setting and design

VLDL-TG concentration and kinetics were evaluated by using stable isotope-labeled tracer techniques in fo

SUBMITTER: Smith GI 

PROVIDER: S-EPMC4079308 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature