Genetic analysis in young-age-of-onset Graves' disease reveals new susceptibility loci.

ABSTRACT:

Context

Genetic and environmental factors play an essential role in the pathogenesis of Graves' Disease (GD). Children with GD have less exposure time to environmental factors and therefore are believed to harbor stronger genetic susceptibility than adults.

Objective

The aim of the study was to identify susceptibility loci that predispose to GD in patients with young-age-of-onset (YAO) GD.

Setting and design

One hundred six patients with YAO GD (onset <30 y) and 855 healthy subjects were studied. Cases and controls were genotyped using the Illumina Infinium Immunochip, designed to genotype 196,524 polymorphisms. Case control association analyses were performed using the PLINK computer package. Ingenuity Pathway Analysis program (QIAGEN) was used to carry out pathway a

SUBMITTER: Brown RS 

PROVIDER: S-EPMC4079314 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature