Integrated analysis of mutation data from various sources identifies key genes and signaling pathways in hepatocellular carcinoma.

ABSTRACT:

Background

Recently, a number of studies have performed genome or exome sequencing of hepatocellular carcinoma (HCC) and identified hundreds or even thousands of mutations in protein-coding genes. However, these studies have only focused on a limited number of candidate genes, and many important mutation resources remain to be explored.

Principal findings

In this study, we integrated mutation data obtained from various sources and performed pathway and network analysis. We identified 113 pathways that were significantly mutated in HCC samples and found that the mutated genes included in these pathways contained high percentages of known cancer genes, and damaging genes and also demonstrated high conservation scores, indicating their important roles in liver tumorigenesis. Fi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4079600 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature