Broad-spectrum β-lactams in obese non-critically ill patients.

ABSTRACT:

Objectives

Obesity may alter the pharmacokinetics of β-lactams. The goal of this study was to evaluate if and why serum concentrations are inadequate when standard β-lactam regimens are administered to obese, non-critically ill patients.

Subjects and methods

During first year, we consecutively included infected, obese patients (body mass index (BMI) ⩾30 kg m(-2)) who received meropenem (MEM), piperacillin-tazobactam (TZP) or cefepime/ceftazidime (CEF). Patients with severe sepsis or septic shock, or those hospitalized in the intensive care unit were excluded. Serum drug concentrations were measured twice during the elimination phase by high-performance liquid chromatography. We evaluated whether free or total drug concentrations were >1 time (fT>minimal inhibition concentrat

SUBMITTER: Hites M 

PROVIDER: S-EPMC4079925 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature