Correlation network analysis reveals relationships between diet-induced changes in human gut microbiota and metabolic health.

ABSTRACT:

Background

Recent evidence suggests that the gut microbiota plays an important role in human metabolism and energy homeostasis and is therefore a relevant factor in the assessment of metabolic health and flexibility. Understanding of these host-microbiome interactions aids the design of nutritional strategies that act via modulation of the microbiota. Nevertheless, relating gut microbiota composition to host health states remains challenging because of the sheer complexity of these ecosystems and the large degrees of interindividual variation in human microbiota composition.

Methods

We assessed fecal microbiota composition and host response patterns of metabolic and inflammatory markers in 10 apparently healthy men subjected to a high-fat high-caloric diet (HFHC, 1300 kcal/d

SUBMITTER: Kelder T 

PROVIDER: S-EPMC4079927 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature