The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes.

ABSTRACT: Integrating the genotype with epigenetic marks holds the promise of better understanding the biology that underlies the complex interactions of inherited and environmental components that define the developmental origins of a range of disorders. The quality of the in utero environment significantly influences health over the lifecourse. Epigenetics, and in particular DNA methylation marks, have been postulated as a mechanism for the enduring effects of the prenatal environment. Accordingly, neonate methylomes contain molecular memory of the individual in utero experience. However, interindividual variation in methylation can also be a consequence of DNA sequence polymorphisms that result in methylation quantitative trait loci (methQTLs) and, potentially, the interaction between fixed genet

SUBMITTER: Teh AL 

PROVIDER: S-EPMC4079963 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature