DNA replication and transcription programs respond to the same chromatin cues.

ABSTRACT: DNA replication is a dynamic process that occurs in a temporal order along each of the chromosomes. A consequence of the temporally coordinated activation of replication origins is the establishment of broad domains (>100 kb) that replicate either early or late in S phase. This partitioning of the genome into early and late replication domains is important for maintaining genome stability, gene dosage, and epigenetic inheritance; however, the molecular mechanisms that define and establish these domains are poorly understood. The modENCODE Project provided an opportunity to investigate the chromatin features that define the Drosophila replication timing program in multiple cell lines. The majority of early and late replicating domains in the Drosophila genome were static across all cell lin

SUBMITTER: Lubelsky Y 

PROVIDER: S-EPMC4079966 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature