Diverse patterns of genomic targeting by transcriptional regulators in Drosophila melanogaster.

ABSTRACT: Annotation of regulatory elements and identification of the transcription-related factors (TRFs) targeting these elements are key steps in understanding how cells interpret their genetic blueprint and their environment during development, and how that process goes awry in the case of disease. One goal of the modENCODE (model organism ENCyclopedia of DNA Elements) Project is to survey a diverse sampling of TRFs, both DNA-binding and non-DNA-binding factors, to provide a framework for the subsequent study of the mechanisms by which transcriptional regulators target the genome. Here we provide an updated map of the Drosophila melanogaster regulatory genome based on the location of 84 TRFs at various stages of development. This regulatory map reveals a variety of genomic targeting patterns, in

SUBMITTER: Slattery M 

PROVIDER: S-EPMC4079976 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature