Project description:Pulmonary arterial hypertension (PAH) is a severe and incurable pulmonary vascular disease. One of the primary origins of PAH is pulmonary endothelial dysfunction leading to vasoconstriction, aberrant angiogenesis and smooth muscle cell proliferation, endothelial-to-mesenchymal transition, thrombosis and inflammation. Our objective was to study the epigenetic variations in pulmonary endothelial cells (PEC) through a specific pattern of DNA methylation. DNA was extracted from cultured PEC from patients with idiopathic PAH (n=11), heritable PAH (n=10) and controls (n=18). ). DNA methylation was assessed using the Illumina HumanMethylation450 Assay. After normalization, samples and probes were clustered according to their methylation profile. Differential clusters were functionally analysed using bioinformatics tools.

2016-07-15 | E-GEOD-84395 | biostudies-arrayexpress

Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension.

Project description: Not available

| S-EPMC9977503 | biostudies-literature

Endothelial DNA methalytion signature in pulmonary arterial hypertension

2016-07-15 | GSE84395 | GEO

Oral treprostinil improves pulmonary vascular compliance in pulmonary arterial hypertension.

Project description: Not available

| S-EPMC10024312 | biostudies-literature

Pulmonary endothelial cell DNA methylation signature in pulmonary arterial hypertension.

Project description: Not available

| S-EPMC5581088 | biostudies-literature

Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.

Project description: Not available

| S-EPMC8035923 | biostudies-literature

Single-cell mRNAseq human pulmonary arterial endothelial cells in healthy and pulmonary arterial hypertension

Project description:We report the single cell transcriptomic profiles of isolated and cultured human pulmonary arterial endothelial cells. Details were published in Scientifc Reports | (2021) 11:14714

2021-10-08 | GSE185479 | GEO

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