Genes associated with genotype-specific DNA methylation in squamous cell carcinoma as candidate drug targets.

ABSTRACT:

Background

Aberrant DNA methylation is often associated with cancers. Thus, screening genes with cancer-associated aberrant DNA methylation is a useful method to identify candidate cancer-causing genes. Aberrant DNA methylation is also genotype dependent. Thus, the selection of genes with genotype-specific aberrant DNA methylation in cancers is potentially important for tailor-made medicine. The selected genes are important candidate drug targets.

Results

The recently proposed principal component analysis based selection of genes with aberrant DNA methylation was applied to genotype and DNA methylation patterns in squamous cell carcinoma measured using single nucleotide polymorphism (SNP) arrays. SNPs that are frequently found in cancers are usually highly methylated, and th

SUBMITTER: Kinoshita R 

PROVIDER: S-EPMC4080267 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature