Transcriptional profiling reveals ductus arteriosus-specific genes that regulate vascular tone.

ABSTRACT: Failure of the ductus arteriosus (DA) to close at birth can lead to serious complications. Conversely, certain profound congenital cardiac malformations require the DA to be patent until corrective surgery can be performed. In each instance, clinicians have a very limited repertoire of therapeutic options at their disposal - indomethacin or ibuprofen to close a patent DA (PDA) and prostaglandin E1 to maintain patency of the DA. Neither treatment is specific to the DA and both may have deleterious off-target effects. Therefore, more therapeutic options specifically targeted to the DA should be considered. We hypothesized the DA possesses a unique genetic signature that would set it apart from other vessels. A microarray was used to compare the genetic profiles of the murine DA and ascending

SUBMITTER: Shelton EL 

PROVIDER: S-EPMC4080279 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature