Resting amygdala and medial prefrontal metabolism predicts functional activation of the fear extinction circuit.

ABSTRACT:

Objective

Individual differences in a person's ability to control fear have been linked to activation in the dorsal anterior cingulate cortex, the ventromedial prefrontal cortex, and the amygdala. This study investigated whether functional variance in this network can be predicted by resting metabolism in these same regions.

Method

The authors measured resting brain metabolism in healthy volunteers with positron emission tomography using [18F]fluorodeoxyglucose. This was followed by a 2-day fear conditioning and extinction training paradigm using functional MRI to measure brain activation during fear extinction and recall. The authors used skin conductance response to index conditioned responding, and they used resting metabolism in the amygdala, the dorsal anterior cingulat

SUBMITTER: Linnman C 

PROVIDER: S-EPMC4080711 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature