Structural genomics reveals EVE as a new ASCH/PUA-related domain.

ABSTRACT: We report on several proteins recently solved by structural genomics consortia, in particular by the Northeast Structural Genomics consortium (NESG). The proteins considered in this study differ substantially in their sequences but they share a similar structural core, characterized by a pseudobarrel five-stranded beta sheet. This core corresponds to the PUA domain-like architecture in the SCOP database. By connecting sequence information with structural knowledge, we characterize a new subgroup of these proteins that we propose to be distinctly different from previously described PUA domain-like domains such as PUA proper or ASCH. We refer to these newly defined domains as EVE. Although EVE may have retained the ability of PUA domains to bind RNA, the available experimental and computatio

SUBMITTER: Bertonati C 

PROVIDER: S-EPMC4080787 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature