Zic-1 Expression in Planarian neoblasts after injury controls anterior pole regeneration.

ABSTRACT: Mechanisms that enable injury responses to prompt regenerative outgrowth are not well understood. Planarians can regenerate essentially any tissue removed by wounding, even after decapitation, due to robust regulation of adult pluripotent stem cells of the neoblast population. Formation of pole signaling centers involving Wnt inhibitors or Wnt ligands promotes head or tail regeneration, respectively, and this process requires the use of neoblasts early after injury. We used expression profiling of purified neoblasts to identify factors needed for anterior pole formation. Using this approach, we identified zic-1, a Zic-family transcription factor, as transcriptionally activated in a subpopulation of neoblasts near wound sites early in head regeneration. As head regeneration proceeds, the Wn

SUBMITTER: Vasquez-Doorman C 

PROVIDER: S-EPMC4081000 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature