Can response-adaptive randomization increase participation in acute stroke trials?

ABSTRACT:

Background and purpose

A response-adaptive randomization (RAR) trial design actively adjusts the ratio of participants assigned to each trial arm, favoring the better performing treatment by using outcome data from participants already in the trial. Compared with a standard clinical trial, an RAR study design has the potential to improve patient participation in acute stroke trials.

Methods

This cross-sectional randomized survey included adult emergency department patients, age≥18, without symptoms of stroke or other critical illness. A standardized protocol was used, and subjects were randomized to either an RAR or standard hypothetical acute stroke trial. After viewing the video describing the hypothetical trial (http://youtu.be/cKIWduCaPZc), reviewing the consent form, an

SUBMITTER: Tehranisa JS 

PROVIDER: S-EPMC4081030 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature