Modelling the interplay between childhood and adult adversity in pathways to psychosis: initial evidence from the AESOP study.

ABSTRACT:

Background

There is evidence that a range of socio-environmental exposures is associated with an increased risk of psychosis. However, despite the fact that such factors probably combine in complex ways to increase risk, the majority of studies have tended to consider each exposure separately. In light of this, we sought to extend previous analyses of data from the AESOP (Aetiology and Ethnicity in Schizophrenia and Other Psychoses) study on childhood and adult markers of disadvantage to examine how they combine to increase risk of psychosis, testing both mediation (path) models and synergistic effects.

Method

All patients with a first episode of psychosis who made contact with psychiatric services in defined catchment areas in London and Nottingham, UK (n = 390) and a serie

SUBMITTER: Morgan C 

PROVIDER: S-EPMC4081841 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature