Ontology highlight
ABSTRACT:
SUBMITTER: Lim X
PROVIDER: S-EPMC4081860 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20131201 6163
The skin is a classical example of a tissue maintained by stem cells. However, the identity of the stem cells that maintain the interfollicular epidermis and the source of the signals that control their activity remain unclear. Using mouse lineage tracing and quantitative clonal analyses, we showed that the Wnt target gene Axin2 marks interfollicular epidermal stem cells. These Axin2-expressing cells constitute the majority of the basal epidermal layer, compete neutrally, and require Wnt/β-caten ...[more]