The relationship between default mode network connectivity and social functioning in individuals at familial high-risk for schizophrenia.

ABSTRACT: Unaffected first-degree relatives of individuals with schizophrenia (i.e., those at familial high-risk [FHR]), demonstrate social dysfunction qualitatively similar though less severe than that of their affected relatives. These social difficulties may be the consequence of genetically conferred disruption to aspects of the default mode network (DMN), such as the dMPFC subsystem, which overlaps with the network of brain regions recruited during social cognitive processes. In the present study, we investigate this possibility, testing DMN connectivity and its relationship to social functioning in FHR using resting-state fMRI. Twenty FHR individuals and 17 controls underwent fMRI during a resting-state scan. Hypothesis-driven functional connectivity analyses examined ROI-to-ROI correlations b

SUBMITTER: Dodell-Feder D 

PROVIDER: S-EPMC4082024 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature