Molecular evolution of NASP and conserved histone H3/H4 transport pathway.

ABSTRACT:

Background

NASP is an essential protein in mammals that functions in histone transport pathways and maintenance of a soluble reservoir of histones H3/H4. NASP has been studied exclusively in Opisthokonta lineages where some functional diversity has been reported. In humans, growing evidence implicates NASP miss-regulation in the development of a variety of cancers. Although a comprehensive phylogenetic analysis is lacking, NASP-family proteins that possess four TPR motifs are thought to be widely distributed across eukaryotes.

Results

We characterize the molecular evolution of NASP by systematically identifying putative NASP orthologs across diverse eukaryotic lineages ranging from excavata to those of the crown group. We detect extensive silent divergence at the nucleotide

SUBMITTER: Nabeel-Shah S 

PROVIDER: S-EPMC4082323 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature