Stochastic simulation of notch signaling reveals novel factors that mediate the differentiation of neural stem cells.

ABSTRACT: Notch signaling controls cell fate decisions and regulates multiple biological processes, such as cell proliferation, differentiation, and apoptosis. Computational modeling of the deterministic simulation of Notch signaling has provided important insight into the possible molecular mechanisms that underlie the switch from the undifferentiated stem cell to the differentiated cell. Here, we constructed a stochastic model of a Notch signaling model containing Hes1, Notch1, RBP-Jk, Mash1, Hes6, and Delta. mRNA and protein were represented as a discrete state, and 334 reactions were employed for each biochemical reaction using a graphics processing unit-accelerated Gillespie scheme. We employed the tuning of 40 molecular mechanisms and revealed several potential mediators capable of enabling th

SUBMITTER: Tzou WS 

PROVIDER: S-EPMC4082354 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature