IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.

ABSTRACT: In a broad attempt to improve the understanding of the genetic regulation of serum IgA levels, the heritability was estimated in over 12 000 Swedish twins, and a genome-wide association study was conducted in a subsample of 9617. Using the classical twin model the heritability was found to be significantly larger among females (61%) compared with males (21%), while contribution from shared environment (20%) was only seen for males. By modeling the genetic relationship matrix with IgA levels, we estimate that a substantial proportion (31%) of variance in IgA levels can ultimately be explained by the investigated SNPs. The genome-wide association study revealed significant association to two loci: (i) rs6928791 located on chromosome 6, 22 kb upstream of the gene SAM and SH3 domain containing

SUBMITTER: Viktorin A 

PROVIDER: S-EPMC4082371 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature