Ontology highlight
ABSTRACT:
SUBMITTER: Heidari Torkabadi H
PROVIDER: S-EPMC4082380 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Biochemistry 20140618 25
Raman microspectroscopy combined with Raman difference spectroscopy reveals the details of chemical reactions within bacterial cells. The method provides direct quantitative data on penetration of druglike molecules into Escherichia coli cells in situ along with the details of drug-target reactions. With this label-free technique, clavulanic acid and tazobactam can be observed as they penetrate into E. coli cells and subsequently inhibit β-lactamase enzymes produced within these cells. When E. c ...[more]