Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.

ABSTRACT:

Background

Only a minority of the genetic components of prostate cancer risk have been explained. Some observed associations of SNPs with prostate cancer might arise from associations of these SNPs with circulating prostate-specific antigen (PSA) because PSA values are used to select controls.

Methods

We undertook a genome-wide association study (GWAS) of screen-detected prostate cancer (ProtecT: 1,146 cases and 1,804 controls); meta-analyzed the results with those from the previously published UK Genetic Prostate Cancer Study (1,854 cases and 1,437 controls); investigated associations of SNPs with prostate cancer using either "low" (PSA < 0.5 ng/mL) or "high" (PSA ≥ 3 ng/mL, biopsy negative) PSA controls; and investigated associations of SNPs with PSA.

Results

The Pr

SUBMITTER: Knipe DW 

PROVIDER: S-EPMC4082405 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature