Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres.

ABSTRACT:

Objective

Gold nanoparticles have attracted enormous interest as potential theranostic agents. However, little is known about the long-term elimination and systemic toxicity of gold nanoparticles in the literature. Hollow gold nanospheres (HAuNS) is a class of photothermal conducting agent that have shown promises in photoacoustic imaging, photothermal ablation therapy, and drug delivery. It's very necessary to make clear the biosafety of HAuNS for its further application.

Methods

We investigated the cytotoxicity, complement activation, and platelet aggregation of polyethylene glycol (PEG)-coated HAuNS (PEG-HAuNS, average diameter of 63 nm) in vitro and their pharmacokinetics, biodistribution, organ elimination, hematology, clinical chemistry, acute toxicity, and chronic tox

SUBMITTER: You J 

PROVIDER: S-EPMC4082425 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature