Complex formation of fenchone with α-cyclodextrin: NMR titrations.

ABSTRACT: ¹³C NMR titration studies of inclusion complexes of bicyclic terpenoid, fenchone enantiomers with α-cyclodextrin revealed their 1:2 guest-host stoichiometry. Sequential binding constants were determined indicating a strong binding cooperativity of two α-cyclodextrin to fenchone. The overall association constants were used to calculate the Gibbs free energies of diastereomeric complex formation, which might be used as a measure of chiral recognition of fenchone by α-cyclodextrin. These results were compared with corresponding data derived for camphor, which is an isomeric bicyclic terpenoid.

SUBMITTER: Nowakowski M 

PROVIDER: S-EPMC4082655 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature