A risk score for the prediction of advanced age-related macular degeneration: development and validation in 2 prospective cohorts.

ABSTRACT:

Purpose

To develop a clinical eye-specific prediction model for advanced age-related macular degeneration (AMD).

Design

The Age-Related Eye Disease Study (AREDS) cohort followed up for 8 years served as the training dataset, and the Blue Mountains Eye Study (BMES) cohort followed up for 10 years served as the validation dataset.

Participants

A total of 4507 AREDS participants (contributing 1185 affected vs. 6992 unaffected eyes) and 2169 BMES participants (contributing 69 affected vs. 3694 unaffected eyes).

Methods

Using Bayes' theorem in a logistic model, we used 8 baseline predictors-age, sex, education level, race, smoking status, and presence of pigment abnormality, soft drusen, and maximum drusen size-to devise and validate a macular risk scoring system (M

SUBMITTER: Chiu CJ 

PROVIDER: S-EPMC4082761 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature